Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm.
Jinghong ShiYucheng WangWei HeZiyue YeMengli LiuZheng ZhaoJacky Wing Yip LamPengfei ZhangRyan Tsz Kin KwokBen Zhong TangPublished in: Molecules (Basel, Switzerland) (2023)
Biofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Therefore, we designed a type I photosensitizer (TTTDM) with an aggregation-induced emission (AIE) property and used F-127 to encapsulate the TTTDM into nanoparticles (F-127 AIE NPs). The NPs exhibit highly efficient ROS generation by enhancing intramolecular D-A interaction and confining molecular non-radiative transitions. Furthermore, the NPs can sufficiently penetrate the biofilm matrix and then detect and eliminate mature bacterial biofilms upon white light irradiation. This strategy holds great promise for the rapid detection and eradication of bacterial biofilms.
Keyphrases
- candida albicans
- pseudomonas aeruginosa
- highly efficient
- human health
- biofilm formation
- staphylococcus aureus
- photodynamic therapy
- risk assessment
- loop mediated isothermal amplification
- helicobacter pylori infection
- fluorescent probe
- living cells
- cystic fibrosis
- cell death
- climate change
- oxide nanoparticles
- single molecule
- escherichia coli
- oxidative stress
- helicobacter pylori
- cancer therapy
- radiation therapy
- drug delivery
- solid state
- deep learning
- machine learning
- quantum dots