Saliva-based linezolid monitoring on a mobile UV spectrophotometer.

Hannah Yejin KimEvelien RuiterErwin M JongedijkHemanth Kumar AkBen J MaraisBhavani PkShailendra SawleshwarkarDaan J TouwJan-Willem Alffenaar

Published in: The Journal of antimicrobial chemotherapy (2021)

We validated a UV spectrophotometric assay using non-invasive saliva sampling for linezolid. The next step is to demonstrate clinical feasibility and value to facilitate programmatic implementation of TDM.

Keyphrases

methicillin resistant staphylococcus aureus
primary care
healthcare
high throughput
aqueous solution
simultaneous determination
tandem mass spectrometry