Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus.
Soumyalekshmi NairDominic GuanzonNanthini JayabalanAndrew LaiKatherin Scholz-RomeroPriyakshi Kalita de CroftValeska OrmazabalCarlos PalmaEmilio DiazElizabeth A McCarthyAlexis ShubJezid MirandaEduard GratacósFátima CrispiGregory DuncombeMartha LappasH David McIntyreGregory RiceCarlos Salomon GalloPublished in: Journal of translational medicine (2021)
During early pregnancy, differently-expressed, EV-associated miRNAs may be of clinical utility in identifying presymptomatic women who will subsequently develop GDM later in gestation. We suggest that miRNA-92a-3p within EVs might be a protected mechanism to increase skeletal muscle insulin sensitivity in GDM.