Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment.
Juha P VäyrynenKoichiro HarukiSara A VäyrynenMai Chan LauAndressa Dias CostaJennifer BorowskyMelissa ZhaoTomotaka UgaiJunko KishikawaNaohiko AkimotoRong ZhongShanshan ShiTzuu-Wang ChangKenji FujiyoshiKota ArimaTyler S TwomblyAnnacarolina Da SilvaMingyang SongKana WuXuehong ZhangAndrew T ChanReiko NishiharaCharles S FuchsJeffrey A MeyerhardtMarios GiannakisShuji OginoJonathan Andrew NowakPublished in: Journal for immunotherapy of cancer (2021)
Myeloid cell populations occur in spatially distinct distributions and exhibit divergent, subset-specific prognostic significance in colorectal cancer, with mature CD14+HLA-DR+ and immature CD14+HLA-DR- monocytic phenotypes most notably showing opposite associations. These results highlight the prognostic utility of multimarker evaluation of myeloid cell infiltrates and reveal a previously unrecognized degree of spatial organization for myeloid cells in the immune microenvironment.