Aging-Associated ALKBH5-m 6 A Modification Exacerbates Doxorubicin-Induced Cardiomyocyte Apoptosis Via AT-Rich Interaction Domain 2.

Runtai Chen Guo-Gang Zhang Kun Sun Alex F Chen

Published in: Journal of the American Heart Association (2023)

A modification in modulating doxorubicin-induced cardiac dysfunction, remodeling, and cardiomyocyte apoptosis in male mice. These results highlight the potential of ALKBH5-targeted treatments for elderly patients with cancer in clinical settings.

Keyphrases

high glucose
oxidative stress
diabetic rats
cancer therapy
endoplasmic reticulum stress
drug delivery
cell death
cell cycle arrest
angiotensin ii
signaling pathway
left ventricular
risk assessment
climate change