A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B.
R El SharkawyK ThabetPietro LamperticoS PettaAlessandra MangiaT BergM MetwallyA BayoumiA BoonstraWillem Pieter BrouwerA SmedileM L AbateA LoglioM W DouglasA KhanR SantoroJ FischerD J LeemingC LiddleJacob GeorgeM EslamPublished in: Alimentary pharmacology & therapeutics (2018)
Genetic susceptibility to HBV persistence, hepatic inflammation and fibrosis in Caucasians associates with STAT4 rs7574865 variant. Downstream effects on NK cell function through STAT4 phosphorylation-dependent IFN-γ production likely contribute to these effects.