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A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B.

R El SharkawyK ThabetPietro LamperticoS PettaAlessandra MangiaT BergM MetwallyA BayoumiA BoonstraWillem Pieter BrouwerA SmedileM L AbateA LoglioM W DouglasA KhanR SantoroJ FischerD J LeemingC LiddleJacob GeorgeM Eslam
Published in: Alimentary pharmacology & therapeutics (2018)
Genetic susceptibility to HBV persistence, hepatic inflammation and fibrosis in Caucasians associates with STAT4 rs7574865 variant. Downstream effects on NK cell function through STAT4 phosphorylation-dependent IFN-γ production likely contribute to these effects.
Keyphrases
  • liver fibrosis
  • hepatitis b virus
  • cell proliferation
  • oxidative stress
  • immune response
  • genome wide
  • dendritic cells
  • african american
  • liver failure
  • dna methylation