Explainable Artificial Intelligence for Predictive Modeling in Healthcare.

The principle behind artificial intelligence is mimicking human intelligence in the way that it can perform tasks, recognize patterns, or predict outcomes through learning from the acquired data of various sources. Artificial intelligence and machine learning algorithms have been widely used in autonomous driving, recommender systems in electronic commerce and social media, fintech, natural language understanding, and question answering systems. Artificial intelligence is also gradually changing the landscape of healthcare research (Yu et al. in Biomed Eng 2:719-731, 25). The rule-based approach that relied on the curation of medical knowledge and the construction of robust decision rules had drawn significant attention in diagnosing diseases and clinical decision support since half a century ago. In recent years, machine learning algorithms such as deep learning that can account for complex interactions between features is shown to be promising in predictive modeling in healthcare (Deo in Circulation 132:1920-1930, 26). Although many of these artificial intelligence and machine learning algorithms can achieve remarkably high performance, it is often difficult to be completely adopted in practical clinical environments due to the lack of explainability in some of these algorithms. Explainable artificial intelligence (XAI) is emerging to assist in the communication of internal decisions, behavior, and actions to health care professionals. Through explaining the prediction outcomes, XAI gains the trust of the clinicians as they may learn how to apply the predictive modeling in practical situations instead of blindly following the predictions. There are still many scenarios to explore how to make XAI effective in clinical settings due to the complexity of medical knowledge.