Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness.

Giovanni Tossetta Sonia FantoneRosaria GesuitaGaia GoteriMartina SenzacquaFabio Marcheggiani Luca TianoDaniela MarzioniRoberta Mazzucchelli

Published in: Cancers (2022)

Our results showed that CNTF and CNTFRa were expressed in PCa and CRPC tissues and that CNTF has a pivotal role in prostate cancer environment remodeling and as a negative modulator of invasion processes of CRPC cell models.

Keyphrases

prostate cancer
radical prostatectomy
signaling pathway
single cell
cell therapy
gene expression
epithelial mesenchymal transition
stem cells
induced apoptosis
endoplasmic reticulum stress