Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin.
Subash Vetri SelviAdhimoorthy PrasannanShen Ming ChenAdhisankar VadivelmuruganHsieh-Chih TsaiJuin-Yih LaiPublished in: Mikrochimica acta (2021)
Two-dimensional (2D) MoS2core-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with L-glutathione and cystamine (L-GSH-MoS2-CYS) using ultrasonic frequency of 20-25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.1-78.3 and 98.3-1218 μM, with a detection limit of 31 nM. A sensitivity of 0.017μA μM-1 cm-2 was acquired at 0.48 V. The fabricated L-GSH-MoS2-CYS modified electrode showed excellent precision, selectivity, repeatability, and reproducibility during the determination of DOX levels in blood serum samples. Thus, the fabricated L-GSH-MoS2-CYS/GCE modified electrode has potential for clinical applications for optimization of chemotherapeutic drugs owing to its selectivity, ease of preparation, and long-term stability. Graphical abstract.
Keyphrases
- quantum dots
- molecularly imprinted
- label free
- reduced graphene oxide
- room temperature
- gold nanoparticles
- loop mediated isothermal amplification
- visible light
- transition metal
- real time pcr
- highly efficient
- solid phase extraction
- drug delivery
- sensitive detection
- ionic liquid
- fluorescent probe
- carbon nanotubes
- hydrogen peroxide
- cancer therapy
- climate change
- risk assessment
- solid state
- crystal structure
- structural basis