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Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation.

Michelle BiljeckiKatharina EisenhutEduardo BeltránStephan WinklmeierSimone MaderAnna ThallerPeter EichhornPhilipp SteiningerAndrea Flierl-HechtJan LewerenzTania KümpfelMartin KerschensteinerEdgar MeinlFranziska S Thaler
Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)
GAD65-specific B cells are present in the CNS and represent a sizable fraction of CSF B cells early in the disease course. The anti-GAD65 response in the CSF is polyclonal and shows evidence of antigen-driven affinity maturation required for GAD65 recognition. Our data support the hypothesis that the accumulation of GAD65-specific B cells and plasma cells in the CSF is an important feature of early disease stages.
Keyphrases
  • induced apoptosis
  • cerebrospinal fluid
  • machine learning
  • electronic health record
  • cell cycle arrest
  • deep learning
  • blood brain barrier
  • oxidative stress
  • cell death
  • signaling pathway
  • cell proliferation
  • neural network