Electrical stimulation or tacrolimus (FK506) alone enhances nerve regeneration and recovery after nerve surgery, while dual use reduces variance and combines strengths of each in promoting enhanced outcomes.
Evan B MarshLauren SchellhardtDaniel A HunterSusan E MackinnonAlison K Snyder-WarwickMatthew D WoodPublished in: Muscle & nerve (2022)
Dual administration of FK506 and E-stim showed minimal additive effects to further improve regeneration or recovery compared with either therapy alone. The data suggest the combination of FK506 and E-stim appears to combine the relative strengths of each therapeutic.