TERT promoter mutation analysis as a surrogate to morphology and immunohistochemistry in problematic spindle cell lesions of the urinary bladder.

Simone BertzRobert StöhrNadine T GaisaBernd WullichArndt HartmannAbbas Agaimy

Published in: Histopathology (2020)

Careful histomorphological analysis and differential IHC reliably distinguish the majority of PSMPs and sarcomatoid UC. In equivocal cases, TERT promoter mutation analysis and/or detection of ALK expression/rearrangements are valuable additional diagnostic adjuncts, strongly supporting sarcomatoid UC and PSMP, respectively.

Keyphrases

gene expression
stem cells
single cell
cell therapy
advanced non small cell lung cancer
sensitive detection