Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer.
Safae TerrisseAnne-Gaelle GoubetKousuke UedaAndrew Maltez ThomasValentin QuiniouCassandra ThelemaqueGarett DunsmoreEmmanuel ClaveMelissa Gamat-HuberSatoru YonekuraGladys FerrereConrad RauberHang Phuong PhamJean-Eudes FahrnerEugenie PizzatoPierre LyMarine FidelleMarine MazzengaCarolina Alves Costa SilvaFederica ArmaniniFederica PintoFrancesco AsnicarRomain DaillèreLisa DerosaCorentin RichardPierre BlanchardBertrand RoutyStéphane CulinePaule OpolonAymeric SilvinFlorent GinhouxAntoine ToubertNicola SegataDouglas G McNeelKarim FizaziGuido KroemerLaurence ZitvogelPublished in: Journal for immunotherapy of cancer (2022)
These findings suggest the potential clinical utility of reversing intestinal dysbiosis and repairing acquired immune defects in PC patients.