Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of Neurofibromatosis Type 1 optic pathway glioma.

Ambrose ChanKailong ZhangGemma MartinSabiha BanoJit ChatterjeeSarvika MahtoAvery WangDavid H GutmannNicole M Brossier

Published in: Neuro-oncology (2024)

These findings establish maternal obesogenic diet as a risk factor for murine Nf1-OPG formation, acting in part through in utero effects on the tumor cell of origin.

Keyphrases

single cell
physical activity
cell therapy
weight loss
signaling pathway
birth weight
pregnancy outcomes
oxidative stress
stem cells
pi k akt
lps induced
nuclear factor
mesenchymal stem cells