Scleraxis and fibrosis in the pressure-overloaded heart.
Raghu S NagalingamSikta ChattopadhyayaDanah S Al-HattabDavid Y C CheungLeah Y SchwartzSayantan JanaNina AroutiounovaD Allison LedinghamTeri L MoffattNatalie M LandryRushita A BagchiIan M C DixonJeffrey T WigleGavin Y OuditZamaneh KassiriDavinder S JassalMichael P CzubrytPublished in: European heart journal (2022)
Scleraxis governs fibroblast activation in pressure overload-induced heart failure, and scleraxis knockout attenuated fibrosis and improved cardiac function and survival. These findings identify scleraxis as a viable target for the development of novel anti-fibrotic treatments.