Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort.
Joanne D SteklerRoss MilneRachel PayantIngrid A BeckJoshua HerbeckBrandon S MaustWenjie DengKenneth TapiaSarah HolteJanine MaenzaClaire E StevensJames I MullinsAnn C CollierLisa M FrenkelPublished in: PLoS medicine (2018)
Drug-resistant majority variants appeared to be commonly transmitted by ARV-naïve participants in our analysis and may contribute significantly to transmitted drug resistance on a population level. When present at low frequency, no major mutation was observed to be shared between partner-pairs; identification of accessory mutations shared within a pair could be due to transmission, laboratory artifact, or apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs), and warrants further study.
Keyphrases
- drug resistant
- hiv testing
- antiretroviral therapy
- multidrug resistant
- acinetobacter baumannii
- men who have sex with men
- crispr cas
- hiv positive
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- physical activity
- copy number
- risk factors
- magnetic resonance imaging
- computed tomography
- binding protein
- pseudomonas aeruginosa
- genome wide
- crystal structure
- cystic fibrosis
- image quality