One-quarter of chronic hepatitis D patients reach HDV-RNA decline or undetectability during the natural course of the disease.
Adriana PalomSara SopenaMar RiveiroAngela Carvalho-GomesAntonio MadejónSergio Rodriguez-TajesLuisa RoadeMaría García-ElizJavier García-SamaniegoSabela LensMarina Berenguer-HaymeFrancisco Rodríguez-FríasHelena Hernandez-ÉvoleAna Isabel Gil-GarcíaAna BarreiraRafael EstebanMaria Buti FerretPublished in: Alimentary pharmacology & therapeutics (2021)
One-quarter of untreated CHD patients showed a ≥2log10 decline in HDV-RNA and 20% reached HDV-RNA undetectability during a mean follow-up of 5.6 years. The decline was associated with ALT decrease. These findings have implications for designing new therapies for CHD.