Insertion site of central venous catheter correlates with catheter-related infectious events in patients undergoing intensive chemotherapy.
Torben RixeckerVadim LesanManfred AhlgrimmLorenz ThurnerMoritz BewarderNiels MurawskiKonstantinos ChristofyllakisSarah AltmeyerAngelika BickStephan StilgenbauerJoerg Thomas BittenbringDominic Kaddu-MulindwaPublished in: Bone marrow transplantation (2020)
Patients undergoing intensive chemotherapy are usually in need for central venous catheters (CVC). Due to contradictory study results, relation of insertion site and CVC-associated complication rate in these patients is not clear. We therefore retrospectively analyzed CVC-related data of all patients undergoing intensive chemotherapy with high risk of febrile neutropenia according to NCCN criteria, who received a CVC at our bone marrow transplantation unit between May 2016 and December 2019. In total, 210 patients received 281 CVC. CVC were placed via either the subclavian-vein (SCV, n = 58; 20%) or the internal-jugular-vein (IJV, n = 223; 80%). Median duration of CVC-lifetime and neutropenic days per CVC were comparable between the two groups (IJV vs SCV: 23 days vs 21 days (p = 0.16) and 12 days vs 11 days (p = 0.65)). Both, time to CVC removal due to local inflammation and time to central line-associated bloodstream infection was significantly shorter in patients with SCV catheters (p = 0.013 and p = 0.045). CVC placed in the IJV were associated with significantly less catheter-related infectious events compared with CVC placed in the SCV. This difference was consistent across different subgroups including 88 patients undergoing allogeneic stem cell transplantation.
Keyphrases
- patients undergoing
- stem cell transplantation
- end stage renal disease
- bone marrow
- ejection fraction
- chronic kidney disease
- newly diagnosed
- high dose
- mesenchymal stem cells
- peritoneal dialysis
- stem cells
- locally advanced
- ultrasound guided
- patient reported outcomes
- radiation therapy
- chemotherapy induced
- escherichia coli
- multidrug resistant
- rectal cancer
- urinary tract infection