Hypercalcemia associated with the interaction between all trans retinoic acid and posaconazole in an acute promyelocytic leukemia case.

Hacer Berna Afacan ÖztürkMurat AlbayrakSenem Maral Merih Reis Aras Fatma Meric Yilmaz Pınar Cömert Mesut Tığlıoğlu Umit Yavuz Malkan

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2021)

This case highlights the importance of monitoring ATRA's side effects when it is used in combination with drugs inhibiting the cytochrome P450 enzymes. In conclusion, the concomitant use of posaconazole and ATRA may lead to hypercalcemia and serum calcium levels return to normal ranges with the discontinuation of these drugs.

Keyphrases

drug induced
liver failure
acute myeloid leukemia
bone marrow
signaling pathway
respiratory failure
aortic dissection