Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving-Williams Series to completely eradicate Staphylococcus aurous .

Khalil MudarmahBijaya BagaleGuanyu ChenJeanette A KrauseJeffrey D MighionSongping D Huang

Published in: Dalton transactions (Cambridge, England : 2003) (2023)

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn(II) ionophore results in the synthesis of Mn(BQ) 2 (DMSO) 2 ·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL -1 ). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.

Keyphrases

metal organic framework
staphylococcus aureus
biofilm formation
pseudomonas aeruginosa
escherichia coli
machine learning
cystic fibrosis
room temperature
artificial intelligence
transition metal