A biocompatible PAA-Cu-MOP hydrogel for wound healing.
Linlin ChenYu QinJing ChengYi ChengZhixiang LuXiaolan LiuShaoxiong YangShuhan LuLi-Yan ZhengQiue CaoPublished in: RSC advances (2020)
Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial properties are urgently needed. Herein, a hydrogel containing poly acrylic acid (PAA), glycerol and Cu-MOP (named PAA-Cu-MOP hydrogel) is obtained by a facile mixing and ultrasonic procedure for wound healing treatment. This PAA-Cu-MOP hydrogel with high biocompatibility exhibits excellent wound healing behavior and is even better than the one of recombinant human epidermal growth factor. Tissue experiment results reveal that the PAA-Cu-MOP hydrogel accelerates the wound healing process by promoting angiogenesis, stimulating cell proliferation, and up-regulating cell factors.
Keyphrases
- wound healing
- growth factor
- metal organic framework
- aqueous solution
- cell proliferation
- recombinant human
- endothelial cells
- single cell
- staphylococcus aureus
- minimally invasive
- drug delivery
- stem cells
- genome wide
- mesenchymal stem cells
- quantum dots
- bone marrow
- gold nanoparticles
- drinking water
- ionic liquid
- dna methylation
- induced pluripotent stem cells
- highly efficient
- tissue engineering
- vascular endothelial growth factor