MD2 Inhibits Choroidal Neovascularization via Antagonizing TLR4/MD2 Mediated Signaling Pathway.

Qi WuZhang ChenChenxin WuLingxi ZhangYuyang WuXiyuan LiuYi WangZong-Duan Zhang

Published in: Current eye research (2023)

Inhibiting MD2 with L2H17 significantly reduced CNV, suppressed inflammation, and oxidative stress by antagonizing TLR4/MD2 pathway in an MD2-dependent manner. MD2 may be a potential therapeutic target and L2H17 may offer an alternative treatment strategy for nAMD.

Keyphrases

molecular dynamics
oxidative stress
signaling pathway
inflammatory response
toll like receptor
immune response
induced apoptosis
pi k akt
ischemia reperfusion injury
climate change
endoplasmic reticulum stress
smoking cessation
optic nerve