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Evolution of Radical-Based Convergent Strategies for Total Syntheses of Densely Oxygenated Natural Products.

Masayuki Inoue
Published in: Accounts of chemical research (2018)
Densely oxygenated natural products often exhibit potent bioactivities and are expected to function as selective cellular probes and novel drug leads. Here we describe our efforts to perfect radical-based convergent strategies for generic total syntheses of these exceedingly challenging structures.
Keyphrases
  • small molecule
  • single molecule
  • anti inflammatory
  • adverse drug
  • mass spectrometry