High Aneuploidy Rates Observed in Embryos Derived from Donated Oocytes are Related to Male Aging and High Percentages of Sperm DNA Fragmentation.

Javier García-FerreyraDaniel LunaLucy VillegasRocío RomeroPatricia ZavalaRoly HilarioJulio Dueñas-Chacón

Published in: Clinical medicine insights. Reproductive health (2015)

Our findings suggest that advanced paternal age increases the aneuploidy rates in embryos from donated oocytes, which suggests that genetic screening is necessary in those egg donor cycles with sperm from patients >50 years old.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
genome wide
circulating tumor
cell free
copy number
patient reported outcomes
gene expression
dna methylation
patient reported