Expanding the toolbox of Baeyer-Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides.
Jingyue WuSilvia AnselmiAlexandra T P CarvalhoJill CaswellDerek J QuinnThomas S MoodyDaniele CastagnoloPublished in: Green chemistry : an international journal and green chemistry resource : GC (2024)
Two new monooxygenase biocatalysts, the Baeyer-Villiger monooxygenase BVMO145 and the flavin monooxygenase FMO401 from Almac library, have been found to catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions. The biocatalyst BVMO145 provides ( S )-sulfoxides while the flavin monooxygenase FMO401 affords ( R )-sulfoxides with good conversions and high ee.