Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Oxana SchmidtNadja NehlsCarolin PrexlerKristina von HeykingTanja GrollKatharina PardonHeathcliff D GarciaTim HenselDennis GürgenAnton G HenssenAngelika EggertKatja SteigerStefan BurdachGuenther H S RichterPublished in: Journal of experimental & clinical cancer research : CR (2021)
Class I HDAC proteins seem to be important mediators of the pathognomonic EWS-ETS-mediated transcription program in EwS and in combination therapy, co-treatment with HDACi is an interesting new treatment opportunity for this malignant disease.