3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha.

Sofia SagredouPanayiotis DalezisNikolaos NikoleousakosMichail Nikolaou Maria VouraKonstantinos AlmpanakisMihalis I Panayiotidis Vasiliki SarliDimitrios T Trafalis

Published in: OncoTargets and therapy (2020)

Among the three triazolo[3,4-b]thiadiazole derivatives, KA39 was shown to be the most potent anticancer agent and catalytic inhibitor of topIIα phosphorylation as well.

Keyphrases

cancer therapy
protein kinase
anti inflammatory
structure activity relationship
crystal structure
drug delivery