Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons.
Yilong DongKangJing PuWenJing DuanHuiCheng ChenLiXing ChenYanMei WangPublished in: BMC neuroscience (2018)
Our data indicate that EPA elicited neuroprotection toward IL-1β-induced cell damage and BDNF decrease and that its effects potentially occurred via the Akt/CREB signaling pathway.
Keyphrases
- signaling pathway
- pi k akt
- diabetic rats
- high glucose
- oxidative stress
- epithelial mesenchymal transition
- endothelial cells
- cell proliferation
- induced apoptosis
- cerebral ischemia
- drug induced
- single cell
- brain injury
- electronic health record
- spinal cord
- spinal cord injury
- bone marrow
- machine learning
- subarachnoid hemorrhage
- big data
- deep learning
- blood brain barrier