Metabolomic profiling reveals the mechanisms underlying the nephrotoxicity of methotrexate in children with acute lymphoblastic leukemia.

Yu ChengYanan ChenMingming ZhaoMinglu WangMaobai LiuLimei Zhao

Published in: Pediatric blood & cancer (2023)

Our findings revealed complex metabolomic profiles and provided novel insights into the mechanism by which ferroptosis contributes to the nephrotoxic effects of methotrexate.

Keyphrases

acute lymphoblastic leukemia
high dose
single cell
cell death
young adults
allogeneic hematopoietic stem cell transplantation
drug induced