Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum.
Francianne M AmorimMaurício L NobreLarissa S NascimentoAlesson M MirandaGlória R G MonteiroFrancisco P Freire-NetoMaria do Carmo Palmeira QueirozJosé W QueirozMalcolm S DuthieMarcos R CostaSteven G ReedWarren D JohnsonKathryn M DupnikSelma M B JeronimoPublished in: PLoS neglected tropical diseases (2019)
Differential co-receptor expression and immunoglobulin levels before and during immune reactions intimate a central role for humoral immunity in RR and ENL. Decreased C4 and elevated anti-M. leprae antibodies in people with new diagnosis of leprosy may be risk factors for subsequent development of leprosy immune reactions.
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