Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia.

Julian L GoggiA HaslopR BoominathanK ChanV SohP ChengE G RobinsK K Bhakoo

Published in: Contrast media & molecular imaging (2019)

Combined treatment with simvastatin and metformin led to a significant improvement in limb angiogenesis, vascular volume, and sustained functional recovery in a diabetic murine model of HLI. PET imaging with [18F]FtRGD provides a robust method for early detection of these proangiogenic effects preclinically and may be useful for the assessment of proangiogenic therapies used clinically to treat diabetic PAD patients.

Keyphrases

pet imaging
wound healing
type diabetes
end stage renal disease
ejection fraction
newly diagnosed
endothelial cells
high resolution
prognostic factors
positron emission tomography
computed tomography
replacement therapy
fluorescence imaging
smoking cessation
pet ct
drug induced
clinical evaluation