Changes in metabolic hormones and trace elements in CSF in active smokers indicate oxidative damage to brain cells.
Peiwen ZhengFan WangHui LiHanlu ChenMengtong LiHaozheng MaJue HeLi ChenYanlong LiuHaiyun XuPublished in: Endocrine connections (2024)
These data relate smoking-induced weight gain to its neurotoxic effect on the neurons that synthesize metabolic hormones such as adiponectin, ghrelin, leptin, or orexin A in the brain, by disrupting mitochondrial function and causing oxidative stress in the neurons.
Keyphrases
- weight gain
- induced apoptosis
- oxidative stress
- diabetic rats
- resting state
- smoking cessation
- body mass index
- white matter
- birth weight
- spinal cord
- functional connectivity
- high glucose
- cell cycle arrest
- metabolic syndrome
- electronic health record
- endoplasmic reticulum stress
- insulin resistance
- dna damage
- big data
- ischemia reperfusion injury
- multiple sclerosis
- endothelial cells
- spinal cord injury
- adipose tissue
- heat shock