HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program.
Ming HuangWen DongRuihui XieJilin WuQiao SuWuguo LiKai YaoYuelong ChenQianghua ZhouQiang ZhangWenwen LiLiang ChengShengmeng PengSiting ChenJian HuangXu ChenTianxin LinPublished in: Cancer communications (London, England) (2022)
Our findings reveal a novel transcriptional program directed by the HSF1-PRMT5-WDR5 axis during the multistep process of lymphatic metastasis in bladder cancer. Targeting HSF1 could be a multipotent and promising therapeutic strategy for bladder cancer patients with lymphatic metastasis.