HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program.

Ming HuangWen DongRuihui XieJilin WuQiao SuWuguo LiKai YaoYuelong ChenQianghua ZhouQiang ZhangWenwen LiLiang ChengShengmeng PengSiting ChenJian HuangXu ChenTianxin Lin

Published in: Cancer communications (London, England) (2022)

Our findings reveal a novel transcriptional program directed by the HSF1-PRMT5-WDR5 axis during the multistep process of lymphatic metastasis in bladder cancer. Targeting HSF1 could be a multipotent and promising therapeutic strategy for bladder cancer patients with lymphatic metastasis.

Keyphrases

heat shock
lymph node
quality improvement
gene expression
transcription factor
heat stress
oxidative stress
genome wide
drug delivery