Disrupting redox homeostasis for tumor therapy based on PDT/chemo/ferroptosis therapeutic hybrid liposomes.
Yuanping HuangHongsen LiuYanfei ZhaoHaoran ChenQiqing LiXiaodan LiShucheng HuaDianbo CaoYulei ChangPublished in: RSC advances (2024)
Synergistic photodynamic therapy (PDT) with other therapeutic modalities can enhance the therapeutic efficacy of tumor treatment and reduce the adverse effects associated with drug leakage and off-target accumulation. However, shaping combined strategies for synergistic therapy remains challenging. Herein, we developed versatile hybrid liposomes self-assembled from Ce6-lipid conjugates and loaded with the chemo drug doxorubicin (DOX) and ferroptosis inducer Fe 3 O 4 nanoparticles for synergistic PDT/chemo/ferroptosis therapy. Abundant ROS are generated by PDT upon 650 nm light irradiation, Fe 3 O 4 -mediated Fenton reaction, and DOX-induced apoptosis. Furthermore, amplifying oxidative stress in cancer cells to disrupt cellular redox homeostasis could accelerate tumor cell death through oxidative damage to lipids, proteins, and DNA. Overall, this work highlights liposome-based therapeutic nanoformulations, thus offering a breakthrough redox homeostasis-based synergistic PDT/chemo/ferroptosis therapy for lung cancer.
Keyphrases
- photodynamic therapy
- cell death
- cancer therapy
- drug delivery
- induced apoptosis
- oxidative stress
- fluorescence imaging
- cell cycle arrest
- endoplasmic reticulum stress
- dna damage
- signaling pathway
- stem cells
- nitric oxide
- combination therapy
- circulating tumor
- ischemia reperfusion injury
- emergency department
- hydrogen peroxide
- drug release
- replacement therapy
- radiation therapy
- cell free
- mesenchymal stem cells
- adverse drug
- rectal cancer
- drug induced
- heat shock