Loss of m6A demethylase ALKBH5 promotes post-ischemic angiogenesis via post-transcriptional stabilization of WNT5A.

Yongchao ZhaoJingjing HuXiaolei SunKun YangLebing YangLingqiu KongBeijian ZhangFuhai LiChaofu LiBei ShiKai HuAijun SunJun-Bo Ge

Published in: Clinical and translational medicine (2022)

We demonstrate that ALKBH5 is a negative regulator of post-ischemic angiogenesis via post-transcriptional modulation and destabilization of WNT5A mRNA in an m6A-dependent manner. Targeting ALKBH5 may be a potential therapeutic option for ischemic diseases, including peripheral artery disease.

Keyphrases

peripheral artery disease
transcription factor
endothelial cells
stem cells
gene expression
ischemia reperfusion injury
vascular endothelial growth factor
heat shock
cancer therapy