Evaluation of the anti-inflammatory effect of 1,4-dihydropyridine derivatives.
Bruno Matheus FacchinTainá Larissa LubschinskiYeo Jim Kinoshita MoonPaula Giarola Fragoso de OliveiraBianca Klafke BeckZiliani da Silva BussLuiz Antonio Escorteganha PolloMaique Weber BiavattiLouis Pergaud SandjoEduardo Monguilhott DalmarcoPublished in: Fundamental & clinical pharmacology (2023)
This compound showed important anti-inflammatory activity, with a significant ability to reduce the production of pro-inflammatory mediators and increase the phagocytic activity of macrophages and anti-inflammatory mediator secretion (IL-10). These findings led us to hypothesize that this compound can repolarize the macrophage response to an anti-inflammatory profile (M2). Moreover, it was also able to maintain its anti-inflammatory activity in vivo experiments.
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