The highly conserved stem-loop II motif is dispensable for SARS-CoV-2.

Hongbing JiangAstha JoshiTianyu GanAndrew B JanowskiChika FujiiTraci L BrickerTamarand L DarlingHouda H HarastaniKuljeet SeehraHongwei ChenStephen TahanAna JungBinita FeblesJoshua A BlatterScott A HandleyBijal A Parikh David Wang Adrianus C M Boon

Published in: bioRxiv : the preprint server for biology (2023)

. We also observed no impact of the deletion on other known RNA structures in the same region of the genome. These experiments demonstrate that the s2m is dispensable for SARS-CoV-2.

Keyphrases

sars cov
respiratory syndrome coronavirus
transcription factor
high resolution
genome wide
mass spectrometry
coronavirus disease