Early Effects of Sacubitril/Valsartan on Exercise Tolerance in Patients with Heart Failure with Reduced Ejection Fraction.

Giuseppe VitaleGiuseppe RomanoAntonino Di FrancoGiuseppa CaccamoCinzia NugaraLaura AjelloSalvo StornioloSilvia SarulloValentina Agnese Francesco GiallauriaGiuseppina NovoFrancesco Clemenza Filippo Maria Sarullo

Published in: Journal of clinical medicine (2019)

Sacubitril/valsartan improved exercise tolerance, LVEF, peak VO₂, and ventilatory efficiency at 6.2 months follow-up. Further studies are necessary to better clarify underlying mechanisms of this functional improvement.

Keyphrases

high intensity
ejection fraction
physical activity
resistance training
case control
body composition