Donor Treg expansion by liposomal α-galactosylceramide modulates Tfh cells and prevents sclerodermatous chronic graft-versus-host disease.

Hiroyuki SugiuraKen-Ichi MatsuokaTakuya FukumiYuichi SumiiTakumi KondoShuntaro IkegawaYusuke MeguriMiki IwamotoYasuhisa SandoMakoto NakamuraTomohiro TojiYasuyuki IshiiYoshinobu Maeda

Published in: Immunity, inflammation and disease (2021)

These data demonstrated an important coordination of T- and B-cell immunity in the pathogenesis of cGVHD and may provide a novel clinical strategy for the induction of immune tolerance after allogeneic HSCT.

Keyphrases

induced apoptosis
hematopoietic stem cell
stem cell transplantation
cell cycle arrest
bone marrow
signaling pathway
cell death
oxidative stress
machine learning
pi k akt
drug induced
artificial intelligence
data analysis