Donor Treg expansion by liposomal α-galactosylceramide modulates Tfh cells and prevents sclerodermatous chronic graft-versus-host disease.
Hiroyuki SugiuraKen-Ichi MatsuokaTakuya FukumiYuichi SumiiTakumi KondoShuntaro IkegawaYusuke MeguriMiki IwamotoYasuhisa SandoMakoto NakamuraTomohiro TojiYasuyuki IshiiYoshinobu MaedaPublished in: Immunity, inflammation and disease (2021)
These data demonstrated an important coordination of T- and B-cell immunity in the pathogenesis of cGVHD and may provide a novel clinical strategy for the induction of immune tolerance after allogeneic HSCT.