Impact of HPV status in T1-2 oropharyngeal squamous cell carcinoma with bulky N3 nodes: a multicenter GETTEC study.

Charles HurelFlorent CarsuzaaJulia SalleronPhilippe GorpheChristian RighiniMaximilien RogéErwan de MonesSylvain MorinièreSébastien VergezJuliette ThariatXavier Dufour

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2022)

In patients with T1-2 oropharyngeal SCC associated with bulky N3 nodes, HPV positive patients without smoking history had better OS and PFS than HPV positive patients with smoking history and HPV negative patients. Thus, HPV status is a significant prognostic factor for survival but this benefit is altered when smoking history is associated. N3 HPV positive patients with smoking history have to be classified as high-risk.

Keyphrases

prognostic factors
high grade
end stage renal disease
squamous cell carcinoma
smoking cessation
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
clinical trial
radiation therapy
early stage
lymph node
lymph node metastasis
neoadjuvant chemotherapy