Association of Interferon Lambda 3 and 4 Gene SNPs and Their Expression with COVID-19 Disease Severity: A Cross-Sectional Study.

Warisha ZahidNida FarooquiNida ZahidKhalid AhmedMuhammad Faraz AnwarSyed Rizwan-Ul-HasanAzhar R HussainAntonio Sarria-Santamera Syed Hani Abidi

Published in: Infection and drug resistance (2023)

Despite the small sample size, IFNL4 gene SNP and patient age were associated with COVID-19 severity. Age, IFNL3/IFNL4 mRNA expression in the nasopharyngeal milieu, and the presence of SNP in the IFNL4 (rs368234815) gene in COVID-19 patients may be biomarkers for infection severity and help improve SARS-CoV-2 infection management.

Keyphrases

genome wide
sars cov
coronavirus disease
copy number
dna methylation
respiratory syndrome coronavirus
genome wide identification
physical activity
gene expression
risk factors
immune response