Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism.

Published in: Cell communication and signaling : CCS (2021)

This study presents a state-of-the-art computational model for investigating the interactions among signaling pathways and environmental stimuli in growth, ageing, metabolism, and diseases. The model can be used as an essential component to simulate gene manipulation, therapies (e.g., rapamycin and wortmannin), calorie restrictions, and chronic stress, and assess their functional implications on longevity and ageing-related diseases. Video Abstract.

Keyphrases

single cell
weight loss
skeletal muscle
stem cells
risk assessment
mesenchymal stem cells
epithelial mesenchymal transition
climate change
stress induced
gene expression
dna methylation
pi k akt
transcription factor
induced apoptosis
human health
drug induced