Supramolecular Assembly of Hybrid Pt(II) Porphyrin/Tomatine Analogues with Different Nanostructures and Cytotoxic Activities.
Mayuko FujitsukaDaisuke IoharaSae OumuraMisaki MatsushimaMina SakuragiMakoto AnrakuTsuyoshi IkedaFumitoshi HirayamaKeita KuroiwaPublished in: ACS omega (2021)
A simple strategy for synthesizing supramolecular hybrids was developed for the preparation of bioavailable nanohybrid photosensitizers by assembling visible-light-sensitive Pt(II) meso-tetrakis(4-carboxyphenyl)porphyrinporphyrin (PtTCPP)/tomatine analogues. The hybrids were self-assembled into nanofibrous or nanosheet structures approximately 3-5 nm thick and several micrometers wide. α-Tomatine generated a unique fibrous vesicle nanostructure based on intermolecular interactions, while dehydrotomatine generated nanosheet structures. Nanoassembly of these fibrous vesicles and sheets directly affected the properties of the light-responsive photosensitizer for tumor photodynamic therapy (PDT), depending on the nanostructure of the hybrid PtTCPP/tomatine analogues. The cytotoxicity of PtTCPP to cancer cells under photoirradiation was significantly enhanced by a tomatine assembly with a fibrous vesicle nanostructure, attributable to increased incorporation of the drug into cells.
Keyphrases
- photodynamic therapy
- molecular docking
- fluorescence imaging
- visible light
- induced apoptosis
- energy transfer
- structure activity relationship
- high resolution
- cancer therapy
- water soluble
- oxidative stress
- molecular dynamics simulations
- endoplasmic reticulum stress
- reduced graphene oxide
- adverse drug
- liquid chromatography