An engineered membrane-bound guanylyl cyclase with light-switchable activity.
Yuehui TianGeorg NagelShiqiang GaoPublished in: BMC biology (2021)
This engineered guanylyl cyclase is the first light-switchable enzyme for cGMP level regulation. Light-regulated cGMP production with high light-sensitivity is a promising technique for the non-invasive investigation of the effects of cGMP signaling in many different tissues.