Coexistent Diabetes Is Associated With the Presence of Adverse Phenotypic Features in Patients With Hypertrophic Cardiomyopathy.
Nicholas JexAmrit ChowdharySharmaine ThirunavukarasuHenry ProcterAnshuman SenguptaPavithra NatarajanSindhoora KothaAna-Maria PoenarPeter SwobodaHui XueRichard M CubbonPeter KellmanJohn P GreenwoodSven PleinStephen PageEylem LeveltPublished in: Diabetes care (2022)
We show for the first time that HCM-DM patients display greater reductions in myocardial energetics, perfusion, and contractile function and higher myocardial scar burden and serum NT-proBNP levels compared with patients with isolated HCM despite similar LV mass and wall thickness and presence of sarcomeric mutations. These adverse phenotypic features may be important components of the adverse clinical manifestation attributable to a combined presence of HCM and T2DM.
Keyphrases
- hypertrophic cardiomyopathy
- left ventricular
- type diabetes
- end stage renal disease
- glycemic control
- heart failure
- ejection fraction
- newly diagnosed
- skeletal muscle
- prognostic factors
- magnetic resonance imaging
- magnetic resonance
- emergency department
- computed tomography
- risk factors
- adipose tissue
- patient reported outcomes
- insulin resistance
- smooth muscle
- weight loss