Stability of a half-sandwich Os(II) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A.

Lukáš MasarykDarina MuthnáPetr HalašPavel ZoufalýEva PeterováRadim Havelek Bohuslav Drahoš David MildeAlena MrkvicováPavel Štarha

Published in: Dalton transactions (Cambridge, England : 2003) (2022)

In the presence of carboxypeptidase, the hydrolytically stable complex [Os(η 6 -pcym)(L2)Cl]PF 6 (2) partially released the bioactive substituent indomethacin, bound through the amide bond to the chelating 2-(1,3,4-thiadiazol-2-yl)pyridine-based moiety of L2. Stability in the presence of other relevant biomolecules (GSH, NADH, GMP) and cancer cell viability were also studied.

Keyphrases

papillary thyroid
quantum dots
squamous cell
biofilm formation
young adults
pseudomonas aeruginosa
fluorescent probe
lymph node metastasis
tissue engineering