Changes of gut microbiota in diabetic nephropathy and its effect on the progression of kidney injury.

Kedan CaiYanhong MaFanghao CaiXiaohan HuangLiang XiaoChenyu ZhongPingping RenQun LuoJianghua ChenFei Han

Published in: Endocrine (2022)

We found the decrease in SCFAs-producing bacteria and low SCFAs concentrations in DN patients. Oral butyrate supplementation may improve kidney injury in DM rats, possibly by increasing autophagy via activating AMPK/mTOR pathway.

Keyphrases

diabetic nephropathy
end stage renal disease
signaling pathway
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
cell proliferation
oxidative stress
endoplasmic reticulum stress