Optimal Significance Levels and Sample Sizes for Signal Detection Methods Based on Non-constant Hazards.
Odile SauzetJulia DyckVictoria CorneliusPublished in: Drug safety (2024)
Based on this study, it is recommended to use the dWSP-pWSP test combination for signal detection with a significance level of 0.004 when the same test is applied to all adverse events not depending on rates.