Natural human Bet v 1-specific IgG antibodies recognize non-conformational epitopes whereas IgE reacts with conformational epitopes.

Georgii Brazhnikov Evgenii Smolnikov Alla Litovkina Tianchi Jiang Artem A Shatilov Inna Tulaeva Mikhail Tulaev Alexander V Karaulov Alina Poroshina Yury V Zhernov Margarete Focke-Tejkl Milena Weber Oluwatoyin Akinfenwa Olga Elisyutina Sergey M Andreev Igor Shilovskiy Nadezhda Shershakova Valeriy V Smirnov Elena Fedenko Tatiana Sergeevna Lepeshkova Evgeny Cronidovich Beltyukov Veronika Victorovna Naumova Michael Kundi Khaitov M R Ursula Wiedermann Rudolph Valenta Raffaela Campana

Published in: Allergy (2023)

IgE and IgG antibodies from BPA patients and birch pollen-exposed non-sensitized subjects recognize different epitopes. These findings explain why natural allergen-specific IgG do not protect against allergic symptoms and suggest that allergen-specific IgE and IgG have different clonal origin.

Keyphrases

end stage renal disease
molecular dynamics
ejection fraction
molecular dynamics simulations
endothelial cells
chronic kidney disease
newly diagnosed
allergic rhinitis
single molecule
prognostic factors
depressive symptoms