Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.

Xutong ZhaoMeng YuYawen ZhaoYiming ZhengLingchao MengKang DuZhiying XieHe LvWei ZhangJing LiuQingqing WangYun YuanZhaoxia WangJianwen Deng

Published in: Journal of neurology (2022)

These findings suggest that increases in ccf-mtDNA levels is associated with the activation of the cGAS-STING pathway, thereby triggering inflammation in MDs.

Keyphrases

cell free
oxidative stress
mitochondrial dna
copy number
gene expression